Effects of HSP-117, a novel tachykinin NK1-receptor antagonist, on cisplatin-induced pica as a new evaluation of delayed emesis in rats

被引：37

作者：

Saeki, M

Sakai, M

Saito, R

Kubota, H

Ariumi, H

Takano, Y

Yamatodani, A

Kamiya, H

机构：

[1] Hisamitsu Pharmaceut Co Inc, Fundamental Res Labs, Tsukuba, Ibaraki 3050856, Japan

[2] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmacol, Fukuoka 8140180, Japan

[3] Osaka Univ, Fac Med, Sch Allied Hlth Sci, Dept Med Phys, Suita, Osaka 5650871, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 2001年 / 86卷 / 03期

关键词：

cisplatin-induced pica; tachykinin NK1-receptor antagonist; delayed emesis;

D O I：

10.1254/jjp.86.359

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of a novel tachykinin NK1-receptor antagonist HSP-117 {(2S,3S)-3-[(5-isopropyI2,3-dihydrobenzofuran-7-yl)methyl]amino-2-phenylpiperidine dihydrochloride on cisplatin-induced pica, i.e., the eating of nonnutritive substances such as kaolin were examined in rats. HSP-117 inhibited kaolin intake in a dose-dependent manner for 2 days. The 5-HT3-receptor antagonist ondansetron inhibited only on the first day, but not on the second day. These results indicate that the cisplatin-induced kaolin intake on the first day is related to both 5-HT3- and NK1 receptors, while only the NK1 receptor is involved on the second day. Thus, cisplatin-induced continuous pica in rats represents a useful model of not only acute but also delayed emesis.

引用

收藏

页码：359 / 362

页数：4

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