Glycosides and xanthine oxidase inhibitors from Conyza bonariensis

被引：59

作者：

Kong, LD

Abliz, Z

Zhou, CX

Li, LJ

Cheng, CHK

Tan, RX ^{[1
]}

机构：

[1] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Inst Funct Biomol, Nanjing 210093, Peoples R China

[2] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China

[3] Beijing Union Med Coll, Beijing 100050, Peoples R China

[4] Chinese Acad Med Sci, Inst Mat Med, Dept Instrumental Anal Determinat Chem Struct, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY | 2001年 / 58卷 / 04期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

Conyza bonariensis; Asteraceae; 4-hydroxypyridin-3-carboxylic acid 4-O-glucopyranoside; 8-hydroxy-6,7-dihydrolinalool 8-O-glucopyranoside; bonaroside; syringic acid; takakin; 8-O-glucuronide;

D O I：

10.1016/S0031-9422(01)00176-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fractionation of the xanthine oxidase inhibitory methanol extract of Conyza bonariensis afforded three glycosides, in addition to nine known compounds including amyrin, beta -sitosterol daucosterol, syringic acid 3-hydroxy-5-methoxybenzoic acid, eugenol 4-O-glucopyranoside, and luteolin, apigenin and takakin 8-O-glucuronide. The structures of the glycosides were established by a com-bination of spectroscopic methods (IR, MS, H-1 and C-13 NMR, DEPT, COSY, HMQC and HMBC) as 4-hydroxypyridin-3-carboxylic acid 4-O-glucopyranoside, 8-hydroxy-6,7-dihydrolinalool 8-O-glucopyranoside and bonaroside [viz. 1,3,4,12-tetrahydroxy-2-(9-hexadecenoylamino)octadecane 1-O-glucopyranoside]. The in vitro enzyme assay showed that syringic acid and takakin 8-O-glucuronide displayed weak inhibitory activity against xanthine oxidase with IC50 values of 500 +/- 41 muM and 170 +/- 12 muM, respectively. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：645 / 651

页数：7

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