Stochastic nanopore sensors for the detection of terrorist agents: Current status and challenges

被引：53

作者：

Liu, Aihua ^{[1
]}

Zhao, Qitao ^{[1
]}

Guan, Xiyun ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

ANALYTICA CHIMICA ACTA | 2010年 / 675卷 / 02期

关键词：

Stochastic sensing; Terrorist agents; Ion channel; Artificial nanopore; Single-channel recording; Real-world sample analysis; RESISTIVE-PULSE; GLASS NANOPORE; POLYNUCLEOTIDE MOLECULES; NANOTUBE MEMBRANES; PROTEIN NANOPORE; ENGINEERED PORE; ION CHANNELS; DNA; BIOSENSORS; DISCRIMINATION;

D O I：

10.1016/j.aca.2010.07.001

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

Nanopore stochastic sensor works by monitoring the ionic current modulations induced by the passage of analytes of interest through a single pore, which can be obtained from a biological ion channel by self-assembly or artificially fabricated in a solid-state membrane. In this minireview, we overview the use of biological nanopores and artificial nanopores for the detection of terrorist agents including explosives, organophosphorus nerve agents, nitrogen mustards, organoarsenic compounds, toxins, and viruses. We also discuss the current challenge in the development of deployable nanopore sensors for real-world applications. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：106 / 115

页数：10

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