High-resolution mapping of the blood pressure QTL on chromosome 7 using Dahl rat congenic strains

被引：55

作者：

Cicila, GT ^{[1
]}

Garrett, MR ^{[1
]}

Lee, SJ ^{[1
]}

Liu, J ^{[1
]}

Dene, H ^{[1
]}

Rapp, JP ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA

来源：

GENOMICS | 2001年 / 72卷 / 01期

关键词：

D O I：

10.1006/geno.2000.6442

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

It was previously shown using Dahl salt-sensitive (S) and salt-resistant (R) rats that a blood pressure quantitative trait locus (QTL) was present on rat chromosome 7. In the present work, this QTL was localized to a region less than 0.54 cM in size on the linkage map using a series of congenic strains. This region was contained in a single yeast artificial chromosome that was 220 kb long. This small segment still contained the primary candidate locus Cyp11b1 (11 beta -hydroxylase), but the adjacent candidate genes Cyp11b2 (aldosterone synthase) and Cyp11b3 were ruled out. It is concluded that 11 beta -hydroxylase, through its known genetic variants altering the production of 18-hydroxy-11-deoxy corticosterone, is very likely to account for the blood pressure QTL on chromosome 7 in the Dahl rat model of hypertension. This QTL accounts for about 23 mm Hg under the condition of 2% NaCl diet for 24 days. (C) 2001 Academic Press.

引用

页码：51 / 60

页数：10

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