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A linkage map of the rat genome derived from three F-2 crosses

被引：134
作者：
Bihoreau, MT
Gauguier, D
Kato, N
Hyne, G
Lindpaintner, K
Rapp, JP
James, MR
Lathrop, GM
机构：
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT CARDIOL,BOSTON,MA 02115
[2] MED COLL OHIO,DEPT PHYSIOL & MOL MED,TOLEDO,OH 43699
来源：
GENOME RESEARCH | 1997年 / 7卷 / 05期
关键词：
D O I：
10.1101/gr.7.5.434
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism, F-2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.
引用
收藏
页码：434 / 440
页数：7
相关论文
共 21 条
  • [1] Construction and characterization of a 10-genome equivalent yeast artificial chromosome library for the laboratory rat, Rattus norvegicus
    Cai, L
    Schalkwyk, LC
    SchoeberleinStehli, A
    Zee, RYL
    Smith, A
    Haaf, T
    Georges, M
    Lehrach, H
    Lindpaintner, K
    [J]. GENOMICS, 1997, 39 (03) : 385 - 392
  • [2] A comprehensive genetic map of the human genome based on 5,264 microsatellites
    Dib, C
    Faure, S
    Fizames, C
    Samson, D
    Drouot, N
    Vignal, A
    Millasseau, P
    Marc, S
    Hazan, J
    Seboun, E
    Lathrop, M
    Gyapay, G
    Morissette, J
    Weissenbach, J
    [J]. NATURE, 1996, 380 (6570) : 152 - 154
  • [3] Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
    Galli, J
    Li, LS
    Glaser, A
    Ostenson, CG
    Jiao, H
    FakhraiRad, H
    Jacob, HJ
    Lander, ES
    Luthman, H
    [J]. NATURE GENETICS, 1996, 12 (01) : 31 - 37
  • [4] Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat
    Gauguier, D
    Froguel, P
    Parent, V
    Bernard, C
    Bihoreau, MT
    Portha, B
    James, MR
    Penicaud, L
    Lathrop, M
    Ktorza, A
    [J]. NATURE GENETICS, 1996, 12 (01) : 38 - 43
  • [5] Genetic mapping of two blood pressure quantitative trait loci on rat chromosome 1
    Gu, LP
    Dene, H
    Deng, AY
    Hoebee, B
    Bihoreau, MT
    James, M
    Rapp, JP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (03) : 777 - 788
  • [6] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS
    HILBERT, P
    LINDPAINTNER, K
    BECKMANN, JS
    SERIKAWA, T
    SOUBRIER, F
    DUBAY, C
    CARTWRIGHT, P
    DEGOUYON, B
    JULIER, C
    TAKAHASI, S
    VINCENT, M
    GANTEN, D
    GEORGES, M
    LATHROP, GM
    [J]. NATURE, 1991, 353 (6344) : 521 - 529
  • [7] A GENETIC-LINKAGE MAP OF THE LABORATORY RAT, RATTUS-NORVEGICUS
    JACOB, HJ
    BROWN, DM
    BUNKER, RK
    DALY, MJ
    DZAU, VJ
    GOODMAN, A
    KOIKE, G
    KREN, V
    KURTZ, T
    LERNMARK, A
    LEVAN, G
    MAO, YP
    PETTERSSON, A
    PRAVENEC, M
    SIMON, JS
    SZPIRER, C
    SZPIRER, J
    TROLLIET, MR
    WINER, ES
    LANDER, ES
    [J]. NATURE GENETICS, 1995, 9 (01) : 63 - 69
  • [8] A RADIATION HYBRID MAP OF 506 STS MARKERS SPANNING HUMAN-CHROMOSOME-11
    JAMES, MR
    RICHARD, CW
    SCHOTT, JJ
    YOUSRY, C
    CLARK, K
    BELL, J
    TERWILLIGER, JD
    HAZAN, J
    DUBAY, C
    VIGNAL, A
    AGRAPART, M
    IMAI, T
    NAKAMURA, Y
    POLYMEROPOULOS, M
    WEISSENBACH, J
    COX, DR
    LATHROP, GM
    [J]. NATURE GENETICS, 1994, 8 (01) : 70 - 76
  • [9] Kosambi D. D., 1944, ANN EUGENICS, V12, P172
  • [10] GENETIC DISSECTION OF COMPLEX TRAITS
    LANDER, ES
    SCHORK, NJ
    [J]. SCIENCE, 1994, 265 (5181) : 2037 - 2048
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