A linkage map of the rat genome derived from three F-2 crosses

被引：134

作者：

Bihoreau, MT

Gauguier, D

Kato, N

Hyne, G

Lindpaintner, K

Rapp, JP

James, MR

Lathrop, GM

机构：

[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT CARDIOL,BOSTON,MA 02115

[2] MED COLL OHIO,DEPT PHYSIOL & MOL MED,TOLEDO,OH 43699

来源：

GENOME RESEARCH | 1997年 / 7卷 / 05期

关键词：

D O I：

10.1101/gr.7.5.434

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the construction of a dense linkage map of the rat genome integrating 767 simple sequence length polymorphism markers, combined over three crosses with high rates of polymorphism, F-2 populations from WKY x S (n = 159), BN x S (n = 91), and BN x GK (n = 139) were selected and genotyped for combinations of microsatellite markers. The loci define 21 linkage groups corresponding to the 20 rat autosomal chromosomes and the X chromosome. The map spans a genetic length of 1998 cM. This combined linkage map should facilitate the advancement of genetic studies for a wide variety of rat models characterized for complex phenotypes.

引用

页码：434 / 440

页数：7

共 21 条

[11] LATHROP GM, 1984, AM J HUM GENET, V36, P460
[12] THE GENE MAP OF THE NORWAY RAT (RATTUS-NORVEGICUS) AND COMPARATIVE MAPPING WITH MOUSE AND MAN
LEVAN, G
SZPIRER, J
SZPIRER, C
KLINGA, K
HANSON, C
ISLAM, MQ
[J]. GENOMICS, 1991, 10 (03) : 699 - 718
[13] LEVAN G, 1990, LOCUS MAPS COMPLEX G
[14] AUTOMATED CONSTRUCTION OF GENETIC-LINKAGE MAPS USING AN EXPERT-SYSTEM (MULTIMAP) - A HUMAN GENOME LINKAGE MAP
MATISE, TC
PERLIN, M
CHAKRAVARTI, A
[J]. NATURE GENETICS, 1994, 6 (04) : 384 - 390
[15] A major quantitative trait locus influences hyperactivity in the WKHA rat
Moisan, MP
Courvoisier, H
Bihoreau, MT
Gauguier, D
Hendley, ED
Lathrop, M
James, MR
Mormede, P
[J]. NATURE GENETICS, 1996, 14 (04) : 471 - 473
[16] A genetic linkage map of the rat derived from recombinant inbred strains
Pravenec, M
Gauguier, D
Schott, JJ
Buard, J
Kren, V
Bila, V
Szpirer, C
Szpirer, J
Wang, JM
Huang, H
StLezin, E
Spence, MA
Flodman, P
Printz, M
Lathrop, GM
Vergnaud, G
Kurtz, TW
[J]. MAMMALIAN GENOME, 1996, 7 (02) : 117 - 127
[17] LINKAGE MAP OF 7 POLYMORPHIC MARKERS ON RAT CHROMOSOME-18
REMMERS, EF
GOLDMUNTZ, EA
ZHA, HB
CROFFORD, LJ
CASH, JM
MATHERN, P
DU, Y
WILDER, RL
[J]. MAMMALIAN GENOME, 1993, 4 (05) : 265 - 270
[18] SERIKAWA T, 1992, GENETICS, V131, P703
[19] Stam P, 1995, JOINMAP TM VERSION 2
[20] STAM P, 1995, PLANT J, V5, P739

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