Liquid chromatography with post-column electrochemical treatment and mass spectrometric detection of non-polar compounds

被引：46

作者：

Diehl, G ^{[1
]}

Liesener, A ^{[1
]}

Karst, U ^{[1
]}

机构：

[1] Univ Munster, Inst Anorgan Chem, D-48149 Munster, Germany

来源：

ANALYST | 2001年 / 126卷 / 03期

关键词：

D O I：

10.1039/b009064f

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The first hyphenation of high performance liquid chromatography (HPLC), electrochemical online oxidation and mass spectrometry (MS) is described. Ferrocenecarboxylic acid esters of various alcohols and phenols have been synthesized, separated by reversed-phase HPLC and oxidized (ionized) coulometrically prior to single quadrupole MS analysis using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) interfaces. The dependence of the ionization on the electrochemical pretreatment is demonstrated. Limits of detection for selected derivatives range from 4 x 10(-9) to 4 x 10(-7) mol dm(-3) depending on the individual compound and the selected interface.

引用

页码：288 / 290

页数：3

共 12 条

[1]

Bayer E, 1999, ANGEW CHEM INT EDIT, V38, P992, DOI 10.1002/(SICI)1521-3773(19990401)38:7<992::AID-ANIE992>3.0.CO

[2]

2-K

[3] ELECTROCHEMICAL THERMOSPRAY MASS-SPECTROMETRY [J].

HAMBITZER, G ;

HEITBAUM, J .

ANALYTICAL CHEMISTRY, 1986, 58 (06) :1067-1070

[4] State-of-the-art in liquid chromatography-mass spectrometry [J].

Niessen, WMA .

JOURNAL OF CHROMATOGRAPHY A, 1999, 856 (1-2) :179-197

[5] Ferrocene-based electroactive derivatizing reagents for the rapid selective screening of alcohols and phenols in natural product mixtures using electrospray-tandem mass spectrometry [J].

Quirke, JME ;

Hsu, YL ;

Van Berkel, GJ .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (02) :230-237

[6] An electrochemical cell for on-line electrochemistry mass spectrometry [J].

Regino, MCS ;

BrajterToth, A .

ANALYTICAL CHEMISTRY, 1997, 69 (24) :5067-5072

[7] Determination of trace amounts of alcohols and phenols in complex mixtures as ferrocenecarboxylic acid esters with gas chromatography atomic emission detection [J].

Rolfes, J ;

Andersson, JT .

ANALYTICAL COMMUNICATIONS, 1996, 33 (12) :429-432

[8] Derivatization for electrospray ionization mass spectrometry. 3. Electrochemically ionizable derivatives [J].

Van Berkel, GJ ;

Quirke, JME ;

Tigani, RA ;

Dilley, AS ;

Covey, TR .

ANALYTICAL CHEMISTRY, 1998, 70 (08) :1544-1554

[9] CHEMICAL DERIVATIZATION FOR ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY .2. AROMATIC AND HIGHLY CONJUGATED MOLECULES [J].

VANBERKEL, GJ ;

ASANO, KG .

ANALYTICAL CHEMISTRY, 1994, 66 (13) :2096-2102

[10] ONLINE ELECTROCHEMISTRY THERMOSPRAY TANDEM MASS-SPECTROMETRY AS A NEW APPROACH TO THE STUDY OF REDOX REACTIONS - THE OXIDATION OF URIC-ACID [J].

VOLK, KJ ;

YOST, RA ;

BRAJTERTOTH, A .

ANALYTICAL CHEMISTRY, 1989, 61 (15) :1709-1717

← 1 2 →