Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration

被引：240

作者：

Xia, Yang ^{[1
,2
,3
]}

Sun, Jianfei ^{[2
]}

Zhao, Liang ^{[3
,4
]}

Zhang, Feimin ^{[1
,5
]}

Liang, Xing-Jie ^{[6
]}

Guo, Yu ^{[1
]}

Weir, Michael D. ^{[3
]}

Reynolds, Mark A. ^{[3
]}

Gu, Ning ^{[2
,5
]}

Xu, Hockin H. K. ^{[3
,7
,8
]}

机构：

[1] Nanjing Med Univ, Jiangsu Key Lab Oral Dis, Nanjing 210029, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Biol Sci & Med Engn, Jiangsu Key Lab Biomat & Devices, Nanjing 210096, Jiangsu, Peoples R China

[3] Univ Maryland, Sch Dent, Dept Adv Oral Sci & Therapeut, Baltimore, MD 21201 USA

[4] Southern Med Univ, Nanfang Hosp, Dept Orthoped Surg, Guangzhou 510515, Guangdong, Peoples R China

[5] Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Jiangsu, Peoples R China

[6] Chinese Acad Sci, Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

[7] Univ Maryland, Sch Med, Ctr Stem Cell Biol & Regenerat Med, Baltimore, MD 21201 USA

[8] Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

BIOMATERIALS | 2018年 / 183卷

基金：

中国国家自然科学基金; 美国国家卫生研究院;

关键词：

Magnetic nanoparticles; Scaffolds; Stem cells; Magnetic forces; Osteogenic differentiation; Bone regeneration; PULSED ELECTROMAGNETIC-FIELDS; SUPERPARAMAGNETIC IRON-OXIDE; BIOACTIVE GLASS SCAFFOLDS; PROMOTES OSTEOGENIC DIFFERENTIATION; MARROW STROMAL CELLS; MRI CONTRAST AGENT; PROGRAMMED FREEZER; IN-VITRO; COMPOSITE SCAFFOLDS; HYDROXYAPATITE SCAFFOLDS;

D O I：

10.1016/j.biomaterials.2018.08.040

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Novel strategies utilizing magnetic nanoparticles (MNPs) and magnetic fields are being developed to enhance bone tissue engineering efficacy. This article first reviewed cutting-edge research on the osteogenic enhancements via magnetic fields and MNPs. Then the current developments in magnetic strategies to improve the cells, scaffolds and growth factor deliveries were described. The magnetic-cell strategies included cell labeling, targeting, patterning, and gene modifications. MNPs were incorporated to fabricate magnetic composite scaffolds, as well as to construct delivery systems for growth factors, drugs and gene transfections. The novel methods using magnetic nanoparticles and scaffolds with magnetic fields and stem cells increased the osteogenic differentiation, angiogenesis and bone regeneration by 2-3 folds over those of the controls. The mechanisms of magnetic nanoparticles and scaffolds with magnetic fields and stem cells to enhance bone regeneration were identified as involving the activation of signaling pathways including MAPK, integrin, BMP and NF-kappa B. Potential clinical applications of magnetic nanoparticles and scaffolds with magnetic fields and stem cells include dental, craniofacial and orthopedic treatments with substantially increased bone repair and regeneration efficacy.

引用

页码：151 / 170

页数：20

共 199 条

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Highly efficient magnetic stem cell labeling with citrate-coated superparamagnetic iron oxide nanoparticles for MRI tracking [J].