A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp.

被引：35

作者：

Chevallier, C

Richardson, AD

Edler, MC

Hamel, E

Harper, MK

Ireland, CM ^{[1
]}

机构：

[1] Univ Utah, Dept Med Chem, Salt Lake City, UT 84112 USA

[2] NCI, Div Canc Treatment & Diagnosis, Dev Therapeut Program, Screening Technol Branch,NIH, Ft Detrick, MD 21702 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 20期

关键词：

D O I：

10.1021/ol035476c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The crude methanol extract of a marine sponge Cymbastela sp. collected in Papua New Guinea was selected for chemical investigation due to its significant cytotoxicity. Fractionation of the extract led to the isolation of jaspamide (1), hemiasterlin (2), milnamide A (3), and a new metabolite, milnamide D (4). The structure was solved by interpretation of NMR and mass spectra data. The cytotoxic and antitubulin activities of milinamide D (4) were evaluated.

引用

页码：3737 / 3739

页数：3

共 10 条

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