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Enantioselective formal [3+3] annulation for the direct construction of bicyclic skeletons with four stereogenic Centers

被引：116
作者：
Cao, Chun-Li [1 ]
Sun, Xiu-Li [1 ]
Kang, Yan-Biao [1 ]
Tang, Yong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China
来源：
ORGANIC LETTERS | 2007年 / 9卷 / 21期
关键词：
D O I：
10.1021/ol701669b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An enantioselective formal [3+3] annulation reaction of cyclic ketones with enones has been developed. In the presence of 20 mol % of pyrrolidine-thiourea la or N-(pyrrolidin-2-ylmethyl)trifluoromethanesulfonamide 1i, the reactions afford bicyclo [3.3.1] adducts in moderate to good yields with good to high enantioselectivities under mild conditions.
引用
收藏
页码：4151 / 4154
页数：4
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