Enantioselectively organocatalytic Michael addition of ketones to alkylidene malonates

被引：63

作者：

Cao, Chun-Li ^{[1
]}

Sun, Xiu-Li ^{[1
]}

Zhou, Jiao-Long ^{[1
]}

Tang, Yong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organomet Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 11期

关键词：

D O I：

10.1021/jo070070p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An organocatalytic asymmetric Michael addition of ketones to alkylidene malonates has been developed. In the presence of 20 mol % of urea 1a or N-(pyrrolidin-2-ylmethyl)trifluoromethanesulfonamide 1j, the reactions of ketones with alkylidene malonates afford the desired Michael adducts in moderate to good yields with good to high enantioselectivities under mild conditions.

引用

页码：4073 / 4076

页数：4

共 66 条

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