Distinct roles of IL-22 in human psoriasis and inflammatory bowel disease

被引：111

作者：

Ouyang, Wenjun ^{[1
]}

机构：

[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 06期

关键词：

IL-22; IBD; Psoriasis; Th17; GENOME-WIDE ASSOCIATION; NATURAL-KILLER-CELLS; PROINFLAMMATORY GENE-EXPRESSION; ACTIVE CROHNS-DISEASE; II CYTOKINE RECEPTOR; INDUCER-LIKE CELLS; TH17; T-CELLS; ROR-GAMMA-T; SKIN INFLAMMATION; INTESTINAL INFLAMMATION;

D O I：

10.1016/j.cytogfr.2010.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-22, an IL-10 family cytokine, is produced by different leukocyte subsets, including T cells, NK cells and lymphoid tissue inducer (LTi) cells. IL-22 mediates the crosstalk between leukocytes and tissue epithelia because its receptor is preferentially expressed on various tissue epithelial cells. IL-22 is essential for host defense against infections of extracellular pathogens, such as bacteria and yeasts, by eliciting various innate defensive mechanisms from tissue epithelial cells and promoting wound-healing responses. In autoimmune diseases, however, diverse tissue microenvironments and underlying pathogenic mechanisms may result in opposing contributions of IL-22 in disease progression. For example, in psoriasis, IL-22 can synergize with other proinflammatory cytokines to induce many of the pathogenic phenotypes from keratinocytes and exacerbate disease progression. In contrast, IL-22 plays a beneficial role in IBD by enhancing barrier integrity and epithelial innate immunity of intestinal tract. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：435 / 441

页数：7

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