Regulation of p53 localization

被引：170

作者：

Liang, SH

Clarke, MF

机构：

[1] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA

[2] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 2001年 / 268卷 / 10期

关键词：

p53 tumor suppressor; nucleocytoplasmic transportation; oligomerization; cytoplasmic sequestration;

D O I：

10.1046/j.1432-1327.2001.02227.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite intensive study of p53, the regulation of p53 cellular localization is still poorly understood. This is an overview of the elements and molecules involved in p53 nucleocytoplasmic transportation. These include the nuclear import and export signals of p53, inhibition of p53 nuclear import and export by oligomerization, MDM2-mediated p53 nuclear export, and possible roles of p53 phosphorylation in regulating p53 cellular localization. Finally, questions regarding p53 cellular trafficking will also be discussed.

引用

收藏

页码：2779 / 2783

页数：5

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