Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears

被引：165

作者：

Diacon, A. H.

Patientia, R. F.

Venter, A.

van Helden, P. D.

Smith, P. J.

McIlleron, H.

Maritz, J. S.

Donald, P. R.

机构：

[1] Univ Stellenbosch, Fac Hlth Sci, Dept Internal Med, ZA-7505 Tygerberg, South Africa

[2] Univ Stellenbosch, Fac Hlth Sci, Dept Mol Biol & Human Genet, ZA-7505 Tygerberg, South Africa

[3] Univ Stellenbosch, Fac Hlth Sci, MRC, Ctr Mol & Cellular Biol,DST,NRF,Ctr Excellence Bi, ZA-7505 Tygerberg, South Africa

[4] Univ Stellenbosch, Fac Hlth Sci, Dept Paediat & Child Hlth, ZA-7505 Tygerberg, South Africa

[5] Univ Cape Town, Div Clin Pharmacol, ZA-7700 Rondebosch, South Africa

[6] S African Med Council, Biostat Unit, Cape Town, South Africa

[7] Karl Bremer Hosp, Tiervlei Trial Ctr, Bellville, South Africa

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期

关键词：

D O I：

10.1128/AAC.01474-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.

引用

页码：2994 / 2996

页数：3

共 21 条

[11]

Mitchison DA, 2000, INT J TUBERC LUNG D, V4, P796

[12]

Peloquin C, 2003, INT J TUBERC LUNG D, V7, P3

[13] Therapeutic drug monitoring in the treatment of tuberculosis [J].