The genetics of TBP and TBP-related factors

被引：61

作者：

Davidson, I ^{[1
]}

机构：

[1] Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, ULP, F-67404 Illkirch Graffenstaden, France

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 07期

关键词：

D O I：

10.1016/S0968-0004(03)00117-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The TATA-binding protein (TBP) has been considered a universal transcription factor that is required for initiation by all three nuclear RNA polymerases. The discovery of TBP-related factors in many metazoan organisms and a mammalian complex that can mediate RNA polymerase II transcription independently of TBP in vitro suggest that TBP might not have such a universal role as previously imagined. Recent genetic and functional analyses reveal that TBP and the TBP-related factors have specific and distinct functions in vivo.

引用

页码：391 / 398

页数：8

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