MITOCHONDRIAL DYNAMICS

被引：58

作者：

Bereiter-Hahn, Juergen ^{[1
]}

Jendrach, Marina ^{[1
]}

机构：

[1] Goethe Univ Frankfurt, Inst Cell Biol & Neurosci, Ctr Excellence Macromol Complexes, Frankfurt, Germany

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 284 | 2010年 / 284卷

关键词：

Mitochondria; Mitochondrial movements; Mitochondrial morphology; Mitochondrial fusion and fission; Calcium; Cytoskeleton; OUTER-MEMBRANE PROTEIN; DIFFERENTIATION-ASSOCIATED PROTEIN-1; GREEN FLUORESCENT PROTEIN; RAT-LIVER MITOCHONDRIA; DIMERIC ATP SYNTHASE; KINESIN HEAVY-CHAIN; AXONAL-TRANSPORT; INNER-MEMBRANE; ENDOPLASMIC-RETICULUM; IN-VIVO;

D O I：

10.1016/S1937-6448(10)84001-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial dynamics is a key feature for the interaction of mitochondria with other organelles within a cell and also for the maintenance of their own integrity. Four types of mitochondrial dynamics are discussed: Movement within a cell and interactions with the cytoskeleton, fusion and fission events which establish coherence within the chondriome, the dynamic behavior of cristae and their components, and finally, formation and disintegration of mitochondria (mitophagy). Due to these essential functions, disturbed mitochondrial dynamics are inevitably connected to a variety of diseases. Localized ATP gradients, local control of calcium-based messaging, production of reactive oxygen species, and involvement of other metabolic chains, that is, lipid and steroid synthesis, underline that physiology not only results from biochemical reactions but, in addition, resides on the appropriate morphology and topography. These events and their molecular basis have been established recently and are the topic of this review.

引用

页码：1 / 65

页数：65

共 484 条

[1] Association between the endoplasmic reticulum and mitochondria of yeast facilitates interorganelle transport of phospholipids through membrane contact [J].