Regulation of serum paraoxonase activity by genetic, nutritional, and lifestyle factors in the general population

被引:135
作者
Ferré, N
Camps, J
Fernández-Ballart, J
Arija, V
Murphy, MM
Ceruelo, S
Biarnés, E
Vilelle, E
Tous, M
Joven, J
机构
[1] Hosp Univ Sant Joan, Ctr Recerca Biomed, Reus 43201, Spain
[2] Univ Rovira & Virgili, Inst Recerca Ciencias Salut, Fac Med, Unitat Med Prevent & Salut Publ, E-43201 Reus, Spain
关键词
D O I
10.1373/49.9.1491
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Background: Paraoxonase may protect lipoproteins and cell membranes from peroxidation, and alterations in the activity of this enzyme have been associated with some chronic diseases. Serum paraoxonase appears to be mainly under genetic control, but some studies suggest that environmental factors may also modulate its activity. The aim of the present study was to investigate whether diet and lifestyle affect serum paraoxonase activity. Methods: We studied a population-based sample of 388 individuals (194 women and 194 men; age range, 18-75 years) and assessed their daily dietary intake using a 3-day estimated food record. The variables studied included serum paraoxonase activity, paraoxonase polymorphisms at positions 55 and 192, age, gender, smoking status, physical exercise, body mass index, energy consumption, nutrient intake (total lipids, saturated fatty acids, beta-carotenes, vitamins C and E), and serum lipid concentrations. Results: Multiple linear regression analysis showed that only genetic polymorphisms, serum cholesterol, HDL-cholesterol concentrations, and cigarette smoking were significant predictors of. serum paraoxonase activity. HDL-cholesterol concentrations were also related to body mass index, daily energy consumption, and saturated fatty acid intake. Conclusions: The between-individual variability of serum paraoxonase activity is regulated mainly by genetic determinants. Although HDL-cholesterol and tobacco smoking may contribute to the modulation of this enzyme, the other nutritional and lifestyle factors do not seem to play a significant role. (C) 2003 American Association for Clinical Chemistry.
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页码:1491 / 1497
页数:7
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