Model studies for molecular recognition of carbonic anhydrase and carboxypeptidase

被引：178

作者：

Kimura, E ^{[1
]}

机构：

[1] Hiroshima Univ, Fac Med, Dept Med Chem, Minami Ku, Hiroshima, Japan

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2001年 / 34卷 / 02期

关键词：

D O I：

10.1021/ar000001w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Model studies using Zn2+ complexes of various derivatives of macrocyclic triamines ([12]aneN(3)) and tetraamines (cyclen) have been found to be useful in elucidating and understanding the intrinsic properties of substrate or inhibitor recognition by zinc ions at the active centers of carbonic anhydrase and carboxypeptidase.

引用

页码：171 / 179

页数：9