Integrin avidity regulation: are changes in affinity and conformation underemphasized?

被引：398

作者：

Carman, CV ^{[1
]}

Springer, TA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Blood Res, Dept Pathol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 05期

关键词：

D O I：

10.1016/j.ceb.2003.08.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Integrins play critical roles in development, wound healing, immunity and cancer. Central to their function is their unique ability to modulate dynamically their adhesiveness through both affinity- and valency-based mechanisms. Recent advances have shed light on the structural basis for affinity regulation and on the signaling mechanisms responsible for both affinity and valency modes of regulation.

引用

页码：547 / 556

页数：10

共 87 条

[1] Three-dimensional model of the human platelet integrin αllbβ3 based on electron cryomicroscopy and x-ray crystallography [J].

Adair, BD ;

Yeager, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (22) :14059-14064

[2] Does the integrin αA domain act as a ligand for its βA domain? [J].

Alonso, JL ;

Essafi, M ;

Xiong, JP ;

Stehle, T ;

Arnaout, MA .

CURRENT BIOLOGY, 2002, 12 (10) :R340-R342

[3] Are changes in integrin affinity and conformation overemphasized? [J].

Bazzoni, G ;

Hemler, ME .

TRENDS IN BIOCHEMICAL SCIENCES, 1998, 23 (01) :30-34

[4]

Bednar B, 1997, CYTOMETRY, V28, P58, DOI 10.1002/(SICI)1097-0320(19970501)28:1<58::AID-CYTO7>3.0.CO

[5]

2-D

[6] Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation [J].

Beglova, N ;

Blacklow, SC ;

Takagi, J ;

Springer, TA .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (04) :282-287

[7] Relationships between Rap1b, affinity modulation of integrin αIIbβ3, and the actin cytoskeleton [J].

Bertoni, A ;

Tadokoro, S ;

Eto, K ;

Pampori, N ;

Parise, LV ;

White, GC ;

Shattil, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (28) :25715-25721

[8] Rap1 signalling: Adhering to new models [J].

Bos, JL ;

de Rooij, J ;

Reedquist, KA .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (05) :369-377

[9] Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1α [J].

Bouvard, D ;

Vignoud, L ;

Dupé-Manet, S ;

Abed, N ;

Fournier, HN ;

Vincent-Monegat, C ;

Retta, SF ;

Fässler, R ;

Block, MR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) :6567-6574

[10] Detection of integrin αIIbβ3 clustering in living cells [J].

Buensuceso, C ;

de Virgilio, M ;

Shattil, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (17) :15217-15224

← 1 2 3 4 5 6 7 8 9 →