Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity.

被引：18

作者：

Hossain, N ^{[1
]}

Hendrix, C ^{[1
]}

Lescrinier, E ^{[1
]}

VanAerschot, A ^{[1
]}

Busson, R ^{[1
]}

DeClercq, E ^{[1
]}

Herdewijn, P ^{[1
]}

机构：

[1] KATHOLIEKE UNIV LEUVEN,REGA INST MED RES,B-3000 LOUVAIN,BELGIUM

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 13期

关键词：

D O I：

10.1016/S0960-894X(96)00254-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Homo-N-nucleosides can be efficiently synthesized from 2-deoxyribose. When incorporated in an oligonucleotide, the compounds have a detrimental influence on duplex stability and on the catalytic activity of hammerhead ribozymes. However, homo-N-nucleosides with a guanine or adenine base moiety do exhibit selective antiviral activity against herpes simplex virus (HSV-1 and HSV-2). Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1465 / 1468

页数：4

共 15 条

[1] COMPARATIVE EFFICACY OF ANTIHERPES DRUGS AGAINST DIFFERENT STRAINS OF HERPES-SIMPLEX VIRUS [J].

DECLERCQ, E ;

DESCAMPS, J ;

VERHELST, G ;

WALKER, RT ;

JONES, AS ;

TORRENCE, PF ;

SHUGAR, D .

JOURNAL OF INFECTIOUS DISEASES, 1980, 141 (05) :563-574

[2] A NOVEL SELECTIVE BROAD-SPECTRUM ANTI-DNA VIRUS AGENT [J].

DECLERCQ, E ;

HOLY, A ;

ROSENBERG, I ;

SAKUMA, T ;

BALZARINI, J ;

MAUDGAL, PC .

NATURE, 1986, 323 (6087) :464-467

[3] COMPUTER-ASSISTED PSEUDOROTATION ANALYSIS OF 5-MEMBERED RINGS BY MEANS OF PROTON SPIN SPIN COUPLING-CONSTANTS - PROGRAM PSEUROT [J].

DELEEUW, FAAM ;

ALTONA, C .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1983, 4 (03) :428-437

[4] Selection of hammerhead ribozymes for optimum cleavage of interleukin 6 mRNA [J].

Hendrix, C ;

Anne, J ;

Joris, B ;

VanAerschot, A ;

Herdewijn, P .

BIOCHEMICAL JOURNAL, 1996, 314 :655-661

[5] CATALYTIC ACTIVITY AND STABILITY OF HAMMERHEAD RIBOZYMES CONTAINING 2'-ACETAMIDO-2'-DEOXYRIBONUCLEOSIDES [J].

HENDRIX, C ;

MAHIEU, M ;

ANNE, J ;

VANCALENBERGH, S ;

VANAERSCHOT, A ;

CONTENT, J ;

HERDEWIJN, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 210 (01) :67-73

[6] NOVEL NUCLEOSIDE STRATEGIES FOR ANTI-HIV AND ANTI-HSV THERAPY [J].

HERDEWIJN, PAMM .

ANTIVIRAL RESEARCH, 1992, 19 (01) :1-14

[7] COMPLEMENTARY-DNA FOR A NOVEL HUMAN INTERLEUKIN (BSF-2) THAT INDUCES LYMPHOCYTES-B TO PRODUCE IMMUNOGLOBULIN [J].

HIRANO, T ;

YASUKAWA, K ;

HARADA, H ;

TAGA, T ;

WATANABE, Y ;

MATSUDA, T ;

KASHIWAMURA, S ;

NAKAJIMA, K ;

KOYAMA, K ;

IWAMATSU, A ;

TSUNASAWA, S ;

SAKIYAMA, F ;

MATSUI, H ;

TAKAHARA, Y ;

TANIGUCHI, T ;

KISHIMOTO, T .

NATURE, 1986, 324 (6092) :73-76

[8] Synthesis of homo-N-nucleosides, a series of C1' branched-chain nucleosides [J].

Hossain, N ;

Blaton, N ;

Peeters, O ;

Rozenski, J ;

Herdewijn, PA .

TETRAHEDRON, 1996, 52 (15) :5563-5578

[9] CONSTRUCTION OF A RIBOZYME DIRECTED AGAINST HUMAN INTERLEUKIN-6 MESSENGER-RNA - EVALUATION OF ITS CATALYTIC ACTIVITY IN-VITRO AND IN-VIVO [J].

MAHIEU, M ;

DESCHUYTENEER, R ;

FORGET, D ;

VANDENBUSSCHE, P ;

CONTENT, J .

BLOOD, 1994, 84 (11) :3758-3765

[10] IN-VITRO NCP7 ENHANCEMENT OF RIBOZYME-MEDIATED CLEAVAGE OF FULL-LENGTH HUMAN IL-6 MESSENGER-RNA [J].

MAHIEU, M ;

HENDRIX, C ;

OOMS, J ;

HERDEWIJN, P ;

CONTENT, J .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 214 (01) :36-43

← 1 2 →