NOVEL NUCLEOSIDE STRATEGIES FOR ANTI-HIV AND ANTI-HSV THERAPY

被引：41

作者：

HERDEWIJN, PAMM

机构：

来源：

ANTIVIRAL RESEARCH | 1992年 / 19卷 / 01期

关键词：

NUCLEOSIDE ANTIVIRAL; TARGETING ANTIVIRAL; HERPES SIMPLEX VIRUS; HUMAN IMMUNODEFICIENCY VIRUS;

D O I：

10.1016/0166-3542(92)90052-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This mini-review describes the structure-activity relationships of several series of new nucleoside analogues. It also points to the possibilities of finding new molecular modifications which could lead to antivirals with activity both against human immunodeficiency viruses (HIV) and herpesviruses.

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页码：1 / 14

页数：14

相关论文

共 51 条

[1] SYNTHESIS AND ANTIHERPETIC ACTIVITY OF (+/-)-9-[[(Z)-2-(HYDROXYMETHYL)CYCLOPROPYL]METHYL]GUANINE AND RELATED-COMPOUNDS [J].

ASHTON, WT ;

MEURER, LC ;

CANTONE, CL ;

FIELD, AK ;

HANNAH, J ;

KARKAS, JD ;

LIOU, R ;

PATEL, GF ;

PERRY, HC ;

WAGNER, AF ;

WALTON, E ;

TOLMAN, RL .

JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (12) :2304-2315

[2] SYNTHESIS AND ANTIVIRAL ACTIVITY OF 9-ALKOXYPURINES .2. 9-(2,3-DIHYDROXYPROPOXY)PURINES, 9-(3,4-DIHYDROXYBUTOXY)PURINES, AND 9-(1,4-DIHYDROXYBUT-2-OXY)PURINES [J].

BAILEY, S ;

HARNDEN, MR ;

JARVEST, RL ;

PARKIN, A ;

BOYD, MR .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) :57-65

[3]

BALZARINI J, 1991, IN PRESS P NATL ACAD, V88

[4] SYNTHESIS OF (+/-)-2'-OXA-CARBOCYCLIC-2',3'-DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS [J].

BAMFORD, MJ ;

HUMBER, DC ;

STORER, R .

TETRAHEDRON LETTERS, 1991, 32 (02) :271-274

[5]

BENNETT LL, 1990, BIOCHEM PHARMACOL, V40, P1515

[6] 2'-DEOXY-2'-FLUORO-ARA-ARISTEROMYCIN, A NEW ANTI-HERPES AGENT - THE 1ST DIRECT INTRODUCTION OF A 2'-FLUORO SUBSTITUENT INTO A CARBOCYCLIC NUCLEOSIDE [J].

BIGGADIKE, K ;

BORTHWICK, AD ;

EXALL, AM ;

KIRK, BE ;

WARD, RA .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1988, (13) :898-900

[7] 4'-MODIFICATION OF CARBOCYCLIC NUCLEOSIDES - SYNTHESIS OF 4'-ALPHA-FLUORO, 4'-ALPHA-HYDROXY AND 4',6'-UNSATURATED DERIVATIVES OF THE ANTIVIRAL AGENT 2'-ARA-FLUORO CARBOCYCLIC GUANOSINE [J].

BIGGADIKE, K ;

BORTHWICK, AD .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1990, (19) :1380-1382

[8] SYNTHESIS OF FLUORINATED CARBOCYCLIC NUCLEOSIDES - PREPARATION OF CARBOCYCLIC 1-(2'-DEOXY-6'-FLUORORIBOFURANOSYL)-5-IODOURACILS [J].

BIGGADIKE, K ;

BORTHWICK, AD ;

EXALL, AM ;

KIRK, BE ;

ROBERTS, SM ;

YOUDS, P ;

SLAWIN, AMZ ;

WILLIAMS, DJ .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (04) :255-256

[9] SYNTHESIS AND ANTIVIRAL ACTIVITY OF ENANTIOMERIC FORMS OF CYCLOBUTYL NUCLEOSIDE ANALOGS [J].

BISACCHI, GS ;

BRAITMAN, A ;

CIANCI, CW ;

CLARK, JM ;

FIELD, AK ;

HAGEN, ME ;

HOCKSTEIN, DR ;

MALLEY, MF ;

MITT, T ;

SLUSARCHYK, WA ;

SUNDEEN, JE ;

TERRY, BJ ;

TUOMARI, AV ;

WEAVER, ER ;

YOUNG, MG ;

ZAHLER, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (04) :1415-1421

[10] FLUORO CARBOCYCLIC NUCLEOSIDES - SYNTHESIS AND ANTIVIRAL ACTIVITY OF 2'-FLUORO AND 6'-FLUORO CARBOCYCLIC PYRIMIDINE NUCLEOSIDES INCLUDING CARBOCYCLIC 1-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-METHYLURACIL AND CARBOCYCLIC 1-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-IODOURACIL [J].

BORTHWICK, AD ;

EVANS, DN ;

KIRK, BE ;

BIGGADIKE, K ;

EXALL, AM ;

YOUDS, P ;

ROBERTS, SM ;

KNIGHT, DJ ;

COATES, JAV .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (01) :179-186

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