N-trans-feruloyltyramine as a melanin biosynthesis inhibitor

被引：35

作者：

Efdi, Mai

Ohguchi, Kenji

Akao, Yukihiro

Nozawa, Yoshinori

Koketsu, Mamoru ^{[1
]}

Ishihara, Hideharu

机构：

[1] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan

[2] Gifu Univ, Fac Engn, Dept Chem, Gifu 5011193, Japan

[3] Gifu Int Inst Biotechnol, Gifu 5040838, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2007年 / 30卷 / 10期

关键词：

melanin; melanogenesis; tyrosinase;

D O I：

10.1248/bpb.30.1972

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.

引用

页码：1972 / 1974

页数：3

共 24 条

[1] Chemical constituents from Annona glabra III [J].