The isolation of secondary metabolites and in vitro potent anti-cancer activity of clerodermic acid from Enicosanthum membranifolium

被引：21

作者：

Efdi, Mai

Itoh, Tomohiro

Akao, Yukihiro

Nozawa, Yoshinori

Koketsu, Mamoru ^{[1
]}

Ishihara, Hideharu

机构：

[1] Gifu Univ, Div Instrumental Anal, Life Sci Res Ctr, Gifu 5011193, Japan

[2] Gifu Univ, Dept Chem, Fac Engn, Gifu 5011193, Japan

[3] Gifu Int Inst Biotechnol, Gifu 5040838, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 11期

关键词：

Enicosanthum membranifolium; apoptosis induction; leukemia cell line HL60;

D O I：

10.1016/j.bmc.2007.03.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four compounds were isolated from Enicosanthum membranifolium. The structures of the compounds were confirmed by spectroscopic data. Their structures were determined as N-trans-feruloyltyramine, R-(-)-mellein, clerodermic acid, and salicifoline chloride as a quaternary alkaloid compound. The structures of R-(-)-mellein and salicifoline chloride were confirmed by using X-ray diffraction. Clerodermic acid was shown to induce potent apoptosis against human leukemia HL60 cells. (c) 2007 Elsevier Ltd. All rights reserved.

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页码：3667 / 3671

页数：5

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