Antitumor agents.: Part 212:: Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras

被引：28

作者：

Hayashi, K

Nakanishi, Y

Bastow, KF

Cragg, G

Nozaki, H

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

[2] NCI, Dev Therapeut Program, Bethesda, MD 20892 USA

[3] Okayama Univ Sci, Dept Biochem, Okayama 7000005, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(01)00742-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As part of a study on antitumor agents from rainforest plants, four new clerodane diterpenes, bucidarasins A-D (1-4), were isolated from Bucida buceras. Their structures were elucidated from detailed 2D NMR analyses. Compounds 1 3 showed potent cytotoxicity against human tumor cell lines with IC50 values of 0.5-1.9 muM. The potency was retained in drug resistant lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：345 / 348

页数：4

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