Four new clerodane diterpenes from the leaves of Casearia guianensis which inhibit the interaction of leukocyte function antigen 1 with intercellular adhesion molecule 1

被引：47

作者：

Hunter, MS ^{[1
]}

Corley, DG ^{[1
]}

Carron, CP ^{[1
]}

Rowold, E ^{[1
]}

Kilpatrick, BF ^{[1
]}

Durley, RC ^{[1
]}

机构：

[1] MONSANTO CO,SEARLE RES & DEV,ST LOUIS,MO 63198

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 09期

关键词：

D O I：

10.1021/np970141n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new clerodane diterpenes, casearinols A and B (1 and 2) and casearinones A and B (3 and 4), were isolated from the leaves of Casearia guianensis. These immunomodulatory compounds have been structurally elucidated primarily on the basis of 2D NMR analysis and spectral data comparison with known compounds. These compounds inhibited the binding of T-cell leukocyte function antigen 1 to intercellular adhesion molecule 1.

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页码：894 / 899

页数：6

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