Novel cytotoxic diterpenes from Casearia arborea

被引：76

作者：

Beutler, JA ^{[1
]}

McCall, KL ^{[1
]}

Herbert, K ^{[1
]}

Herald, DL ^{[1
]}

Pettit, GR ^{[1
]}

Johnson, T ^{[1
]}

Shoemaker, RH ^{[1
]}

Boyd, MR ^{[1
]}

机构：

[1] NCI, Frederick Canc Res & Dev Ctr, Div Canc Treatment & Diag, Dev Therapeut Program,Lab Drug Discovery Res & De, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 05期

关键词：

D O I：

10.1021/np990553r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cytotoxicity-guided fractionation of the dichloromethane-methanol extract of the roots of Casearia arborea yielded five novel clerodane diterpenes, casearborins A-E (1-5), as well as cucurbitacin B. The presence of cucurbitacins glycosides was also detected. The absolute configuration of casearborin E was determined by X-ray crystallography.

引用

页码：657 / 661

页数：5

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