Two sides of a cellular coin:: CD4+CD3- cells regulate memory responses and lymph-node organization

被引：68

作者：

Lane, PJL ^{[1
]}

Gaspal, FMC ^{[1
]}

Kim, MY ^{[1
]}

机构：

[1] Univ Birmingham Sch Med, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2005年 / 5卷 / 08期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri1665

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We propose that CD4(+)CD3(-) cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses. As CD4(+)CD3(-) cells express the HIV co-receptors CD4 and CXC-chemokine receptor 4, we think that infection of these cells by HIV, and their subsequent destruction by the host immune system, could help to explain the loss of memory antibody responses and the destruction of lymphoid architecture that occur during disease progressionto AIDS.

引用

页码：655 / 660

页数：6

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