Enforcing ostwald's rule of stages: Isolation of paracetamol forms III and II

被引：85

作者：

Burley, Jonathan C. ^{[1
]}

Duer, Melinda J.

Stein, Robin S.

Vrcelj, Ranko M.

机构：

[1] De Montfort Univ, Leicester Sch Pharm, Hawthorn Bldg, Leicester LE1 9BH, Leics, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[3] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 1EW, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2007年 / 31卷 / 05期

关键词：

polymorphism; crystallisation; amorphous materials; paracetamol; HIGHLY COMPRESSIBLE PARACETAMOL; ORTHORHOMBIC PARACETAMOL; CRYSTALLIZATION; CRYSTALS;

D O I：

10.1016/j.ejps.2007.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have been able to isolate and study the polymorphic form III of paracetamol using a specially designed methodology. Our work represents the first report of a reproducible, reliable route to form III. This has been an outstanding problem for over quarter of a century. Our method may be applicable to the isolation of metastable polymorphs of other compounds. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：271 / 276

页数：6

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