Enforcing ostwald's rule of stages: Isolation of paracetamol forms III and II

被引：85

作者：

Burley, Jonathan C. ^{[1
]}

Duer, Melinda J.

Stein, Robin S.

Vrcelj, Ranko M.

机构：

[1] De Montfort Univ, Leicester Sch Pharm, Hawthorn Bldg, Leicester LE1 9BH, Leics, England

[2] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

[3] Univ Cambridge, Dept Mat Sci & Met, Cambridge CB2 1EW, England

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2007年 / 31卷 / 05期

关键词：

polymorphism; crystallisation; amorphous materials; paracetamol; HIGHLY COMPRESSIBLE PARACETAMOL; ORTHORHOMBIC PARACETAMOL; CRYSTALLIZATION; CRYSTALS;

D O I：

10.1016/j.ejps.2007.04.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have been able to isolate and study the polymorphic form III of paracetamol using a specially designed methodology. Our work represents the first report of a reproducible, reliable route to form III. This has been an outstanding problem for over quarter of a century. Our method may be applicable to the isolation of metastable polymorphs of other compounds. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：271 / 276

页数：6

共 25 条

[21] Spectroscopic characterisation of the monoclinic and orthorhombic forms of paracetamol [J].

Moynihan, HA ;

O'Hare, IP .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2002, 247 (1-2) :179-185

[22] Physicochemical characterization of the orthorhombic polymorph of paracetamol crystallized from solution [J].

Nichols, G ;

Frampton, CS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1998, 87 (06) :684-693

[23]

Ostwald W., 1897, Z PHYS CHEM, V22, P289, DOI DOI 10.1515/ZPCH-1897-2233

[24] Iterative high-throughput polymorphism studies on acetaminophen and an experimentally derived structure for form III [J].

Peterson, ML ;

Morissette, SL ;

McNulty, C ;

Goldsweig, A ;

Shaw, P ;

LeQuesne, M ;

Monagle, J ;

Encina, N ;

Marchionna, J ;

Johnson, A ;

Gonzalez-Zugasti, J ;

Lemmo, AV ;

Ellis, SJ ;

Cima, MJ ;

Almarsson, Ö .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (37) :10958-10959

[25] Solid-state characterization of paracetamol metastable polymorphs formed in binary mixtures with hydroxypropylmethylcellulose [J].

Rossi, A ;

Savioli, A ;

Bini, M ;

Capsoni, D ;

Massarotti, V ;

Bettini, R ;

Gazzaniga, A ;

Sangalli, ME ;

Giordano, F .

THERMOCHIMICA ACTA, 2003, 406 (1-2) :55-67

← 1 2 3 →