Orexinergic innervation of POMC-containing neurons in the rat arcuate nucleus

被引：54

作者：

Guan, JL

Saotome, T

Wang, QP

Funahashi, H

Hori, T

Tanaka, S

Shioda, S

机构：

[1] Showa Univ, Sch Med, Dept Anat, Shinagawa Ku, Tokyo 1428555, Japan

[2] Shizuoka Univ, Fac Sci, Dept Biol, Shizuoka 4228529, Japan

来源：

NEUROREPORT | 2001年 / 12卷 / 03期

关键词：

arcuate nucleus; electron microscopy; immunostaining; orexin; POMC; synapse;

D O I：

10.1097/00001756-200103050-00023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A pre-embedding double immunostaining technique was used to study the synaptic relationships between orexin-like immunoreactive axon terminals and preopiomelanocortin (POMC)like immunoreactive neurons in the rat arcuate nucleus. Most of the synapses were axo-dendritic, while some axo-somatic synapses were also found. Both the axo-somatic and axodendritic synapses were symmetrical. In some cases the presynaptic orexin-like immunoreactive axon terminals contained a few large dense-cored vesicles. The results suggest that the orexinergic axon terminals in the arcuate nucleus may play an important role in the regulation of food intake via synapses through POMC neurons. NeuroReport 12:547-551 (C) 2001 Lippincott Williams & Wilkins.

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页码：547 / 551

页数：5

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