Microsome-mediated transformation of O-methylandrocymbine to demecolcine and colchicine

被引：13

作者：

Rueffer, M ^{[1
]}

Zenk, MH ^{[1
]}

机构：

[1] Univ Munich, Lehrstuhl Pharmazeut Biol, D-80333 Munich, Germany

来源：

FEBS LETTERS | 1998年 / 438卷 / 1-2期

关键词：

colchicine biosynthesis; demecolcine; ring expansion reaction; Colchicum autumnale;

D O I：

10.1016/S0014-5793(98)01282-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O-2 In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and NADPH. (C) 1998 Federation of European Biochemical Societies.

引用

页码：111 / 113

页数：3

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