A weak signal for strong responses:: Interferon-α/β revisited

被引：408

作者：

Taniguchi, T

Takaoka, A

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan

[2] Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 05期

关键词：

D O I：

10.1038/35073080

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Biological systems have acquired adaptability and robustness against rapid environmental changes. A typical example is the immune system, which eradicates invading pathogens such as viruses, interferons alpha and beta, which are produced in response to viral infection, are essential components of this system but are also produced at low levels in the absence of infection. What is the purpose of the constitutive weak interferon-alpha/beta signal?

引用

页码：378 / 386

页数：9

共 94 条

[1] IFN-α and IFN-β: A link between immune memory and chronic inflammation
Akbar, AN
Lord, JM
Salmon, M
[J]. IMMUNOLOGY TODAY, 2000, 21 (07): : 337 - +
[2] The IFN gamma receptor: A paradigm for cytokine receptor signaling
Bach, EA
Aguet, M
Schreiber, RD
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 : 563 - &
[3] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING
BERRIDGE, MJ
[J]. NATURE, 1993, 361 (6410) : 315 - 325
[4] BILIAU A, 1996, ADV IMMUNOL, V62, P61
[5] Natural killer cells in antiviral defense: Function and regulation by innate cytokines
Biron, CA
Nguyen, KB
Pien, GC
Cousens, LP
Salazar-Mather, TP
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 189 - 220
[6] Bluyssen Hans A. R., 1996, Cytokine and Growth Factor Reviews, V7, P11, DOI 10.1016/1359-6101(96)00005-6
[7] THE PHYSIOLOGICAL INTERFERON RESPONSE
BOCCI, V
[J]. IMMUNOLOGY TODAY, 1985, 6 (01): : 7 - 9
[8] Functions of lipid rafts in biological membranes
Brown, DA
London, E
[J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 1998, 14 : 111 - 136
[9] Lineage-specific activation of STAT3 by interferon-γ in human neutrophils
Caldenhoven, E
Buitenhuis, M
van Dijk, TB
Raaijmakers, JAM
Lammers, JWJ
Koenderman, L
de Groot, RP
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1999, 65 (03) : 391 - 396
[10] COFFER P, 1995, ONCOGENE, V10, P985

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