Dynamics of annual influenza A epidemics with immuno-selection

被引:60
作者
Andreasen, V [1 ]
机构
[1] Roskilde Univ, Dept Math & Phys, DK-4000 Roskilde, Denmark
关键词
infectious disease; influenza drift; cross-immunity; seasonal epidemics; iterated map;
D O I
10.1007/s00285-002-0186-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The persistence of Influenza A in the human population relies on continual changes in the viral surface antigens allowing the virus to reinfect the same hosts every few years. The epidemiology of such a drifting virus is modeled by a discrete season-to-season map. During the epidemic season only one strain is present and its transmission dynamics follows a standard epidemic model. After the season, cross-immunity to next year's virus is determined from the proportion of hosts that were infected during the season. A partial analysis of this map shows the existence of oscillations where epidemics occur at regular or irregular intervals.
引用
收藏
页码:504 / 536
页数:33
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