Dynamics of annual influenza A epidemics with immuno-selection

被引:60
作者
Andreasen, V [1 ]
机构
[1] Roskilde Univ, Dept Math & Phys, DK-4000 Roskilde, Denmark
关键词
infectious disease; influenza drift; cross-immunity; seasonal epidemics; iterated map;
D O I
10.1007/s00285-002-0186-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The persistence of Influenza A in the human population relies on continual changes in the viral surface antigens allowing the virus to reinfect the same hosts every few years. The epidemiology of such a drifting virus is modeled by a discrete season-to-season map. During the epidemic season only one strain is present and its transmission dynamics follows a standard epidemic model. After the season, cross-immunity to next year's virus is determined from the proportion of hosts that were infected during the season. A partial analysis of this map shows the existence of oscillations where epidemics occur at regular or irregular intervals.
引用
收藏
页码:504 / 536
页数:33
相关论文
共 64 条
[31]   THE SPREAD OF EPIDEMICS [J].
GLEISSNER, W .
APPLIED MATHEMATICS AND COMPUTATION, 1988, 27 (02) :167-171
[32]   THE INFLUENZA HERALD WAVE [J].
GLEZEN, WP ;
COUCH, RB ;
SIX, HR .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1982, 116 (04) :589-598
[33]   A status-based approach to multiple strain dynamics [J].
Gog, JR ;
Swinton, J .
JOURNAL OF MATHEMATICAL BIOLOGY, 2002, 44 (02) :169-184
[34]  
GOG JR, 2002, IN PRESS P NATL ACAD
[35]  
Gomes MGM, 2002, IMA VOL MATH APPL, V126, P171
[36]   THEORETICAL-STUDIES OF THE EFFECTS OF HETEROGENEITY IN THE PARASITE POPULATION ON THE TRANSMISSION DYNAMICS OF MALARIA [J].
GUPTA, S ;
SWINTON, J ;
ANDERSON, RM .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 256 (1347) :231-238
[37]   Chaos, persistence, and evolution of strain structure in antigenically diverse infectious agents [J].
Gupta, S ;
Ferguson, N ;
Anderson, R .
SCIENCE, 1998, 280 (5365) :912-915
[38]  
Hethcote HW., 1989, Applied Mathematical Ecology, P119, DOI DOI 10.1007/978-3-642-61317-3_5
[39]  
HETHCOTE HW, 1974, MATH PROBLEMS BIOL, P83
[40]   Kermack and McKendrick revisited: The variable susceptibility model for infectious diseases [J].
Inaba, H .
JAPAN JOURNAL OF INDUSTRIAL AND APPLIED MATHEMATICS, 2001, 18 (02) :273-292