Retardation of brain aging by chronic treatment with melatonin

被引:17
作者
Bondy, SC [1 ]
Lahiri, DK
Perreau, VM
Sharman, KZ
机构
[1] Univ Calif Irvine, Dept Community & Environm Med, Irvine, CA 92697 USA
[2] Indiana Univ, Sch Med, Inst Psychiat Res, Indianapolis, IN 46202 USA
[3] Univ Calif Irvine, Inst Brain Aging & Dementia, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 USA
来源
PROTECTIVE STRATEGIES FOR NEURODEGENERATIVE DISEASES | 2004年 / 1035卷
关键词
brain aging; melatonin; antioxidants; neurodegenerative disease; inflammation;
D O I
10.1196/annals.1332.013
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Slowing the functional decline in the aging brain is not only relevant to nonpathological senescence but also to a broad range of neurodegenerative diseases. Although disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD) are not found in the young adult, they gradually manifest with increasing age. AD, in particular, is an increasing major public health concern as the population ages; therapies that delay disease onset will markedly reduce overall disease prevalence. Aging of the brain has been repeatedly associated with cumulative oxidative damage to macromolecules and to abnormal levels of inflammatory activity. Melatonin has attained increasing prominence as a candidate for ameliorating these changes occurring during senescence. Recent research has focused on supplementation with dietary melatonin designed to elucidate the specific key intracellular targets of age-related inflammatory events, and the optimal means of affording protection of these targets. This report summarizes the progress made in this area.
引用
收藏
页码:197 / 215
页数:19
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