Inhibitory effect of soybean hypocotyls on Epstein-Barr virus early antigen induction and skin tumor promotion

被引：6

作者：

Zaizen, Y

Tokuda, H

Nishino, H

Takeshita, M

机构：

[1] OITA MED UNIV, DEPT BIOCHEM, OITA 87955, JAPAN

[2] KYOTO PREFECTURAL UNIV MED, DEPT BIOCHEM, KAMIGYO KU, KYOTO 602, JAPAN

来源：

CANCER LETTERS | 1997年 / 121卷 / 01期

关键词：

soybean hypocotyl; anti-tumor promoting effect; Epstein-Barr virus early antigen; mouse skin tumor; isoflavonoid;

D O I：

10.1016/S0304-3835(97)00335-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The in vitro anti-tumor promoting effect of hypocotyls from fresh soybeans was evaluated. The dimethyl sulfoxide extracts of hypocotyls showed a stronger inhibitory effect than that of soybeans on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate. Daidzin, an isoflavone with the highest content of hypocotyls, was also inhibitory. An in vivo evaluation of anti-tumor promoting activity of hypocotyls against the skin of mice also revealed a significant inhibitory effect on tumor formation. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：53 / 57

页数：5

共 22 条

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