The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

被引：146

作者：

Hrabal, R

Chen, ZG

James, S

Bennett, HPJ

Ni, F

机构：

[1] NATL RES COUNCIL CANADA,BIOTECHNOL RES INST,MONTREAL,PQ H4P 2R2,CANADA

[2] NATL RES COUNCIL CANADA,MONTREAL JOINT CTR STRUCT BIOL,MONTREAL,PQ H4P 2R2,CANADA

[3] MCGILL UNIV,ROYAL VICTORIA HOSP,ENDOCRINE LAB,MONTREAL,PQ H3A 1A1,CANADA

[4] MCGILL UNIV,DEPT MED,MONTREAL,PQ H3A 1A1,CANADA

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 09期

关键词：

D O I：

10.1038/nsb0996-747

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of β-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.

引用

页码：747 / 752

页数：6

共 30 条

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