Toward partial fucosyl transferase transition state analogues:: methylene sulfono sulfonamide as surrogate of pyrophosphate

被引：8

作者：

Carchon, G ^{[1
]}

Chrétien, F ^{[1
]}

Chapleur, Y ^{[1
]}

机构：

[1] Univ Nancy 1, Grp SUCRES, CNRS, UMR 7565,INCM, F-54506 Vandoeuvre Les Nancy, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 30期

关键词：

D O I：

10.1016/S0040-4039(03)01305-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Partial fucosyl transferase transition state analogues having sulfonoacetamido- and methylene sulfono sulfonamide links as a non-charged surrogate of the pyrophosphate moiety have been prepared from fructose and guanosine. The use of a MOM group at N1 and a formamidine group at the primary amine function for the protection of the guanine residue proved troublesome. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：5715 / 5718

页数：4

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