Hyperresponsiveness to phencyclidine in animals lesioned in the amygdala on day 7 of life - Implications for an animal model of schizophrenia

被引：16

作者：

Daenen, EWPM ^{[1
]}

Wolterink, G ^{[1
]}

Van Ree, JM ^{[1
]}

机构：

[1] Univ Utrecht, Med Ctr, Dept Pharmacol & Anat, Rudolf Magnus Inst Neurosci, NL-3508 AB Utrecht, Netherlands

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2003年 / 13卷 / 04期

关键词：

animal model; phencyclidine; schizophrenia; amygdala; locomotor activity; hypersensitivity;

D O I：

10.1016/S0924-977X(03)00029-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Phencyclidine (PCP) has been described to exacerbate psychotic symptoms in patients suffering from schizophrenia. In rats, PCP, dose-dependently, induces hyperactivity, stereotyped behaviour and social isolation, postulated to represent the positive (hyperactivity, stereotypy) and negative (social isolation) symptoms of schizophrenia. Based on previous studies, ibotenic acid lesions in the amygdala on day 7 of life have been proposed as an animal model of psychiatric neurodevelopmental disorders like schizophrenia. The purpose of the present study was to determine whether the responsiveness to PCP on locomotor activity in animals lesioned in the amygdala on day 7 of life is different from the response to this drug in sham-operated animals. The effect of graded doses of PCP on behaviour was assessed in a small open field. Animals lesioned in the arnygdala on day 7 of life appeared to be hyperresponsive to PCP compared to sham-operated animals. The hyperresponsiveness to PCP in rats lesioned in the amygdala on day 7 of life further contributes to the validation of this putative animal model of schizophrenia. (C) 2003 Elsevier B.V./ECNP. All rights reserved.

引用

页码：273 / 279

页数：7

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