Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (GADD45β) gene

被引：14

作者：

Balliet, AG ^{[1
]}

Hatton, KS ^{[1
]}

Hoffman, B ^{[1
]}

Lieberman, DA ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Biochem, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19104 USA

来源：

DNA AND CELL BIOLOGY | 2001年 / 20卷 / 04期

关键词：

D O I：

10.1089/104454901750219125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MyD118 (Gadd45 beta) protein is a member of a family of structurally related proteins, including Gadd45 (Gadd45 alpha) and CR6 (Gadd45 gamma), that have critical roles in regulating growth arrest and apoptosis, The MyD118 and other members of its family display distinct patterns of expression in response to stimuli that induce differentiation, growth arrest, or apoptosis. Species-blot analysis showed that MyD118 is an evolutionarily conserved gene, and comparative sequence analysis showed that MyD118 has a gene structure similar to that of other members of its gene family. Comparison of putative transcription factor-binding sites found in sequences of this gene family provides evidence that p53 is involved in regulating the expression of MyD118 and that NF-kappaB may play a role in differential expression of MyD118 and Gadd45(Gadd45a). fluorescence in situ hybridization localized the MyD118 gene to mouse chromosome band 10B5.3, correcting a previous assignment to mouse chromosome 9.

引用

页码：239 / 247

页数：9

共 29 条

[1]

ABDOLLAHI A, 1991, ONCOGENE, V6, P165

[2]

ALIMZHANOV MB, 1993, DOKL AKAD NAUK+, V333, P788

[3] Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis [J].

Brady, KP ;

Rowe, LB ;

Her, H ;

Stevens, TJ ;

Eppig, J ;

Sussman, DJ ;

Sikela, J ;

Beier, DR .

GENOME RESEARCH, 1997, 7 (11) :1085-1093

[4] c-myc null cells misregulate cad and gadd45 but not other proposed c-Myc targets [J].

Bush, A ;

Mateyak, M ;

Dugan, K ;

Obaya, A ;

Adachi, S ;

Sedivy, J ;

Cole, M .

GENES & DEVELOPMENT, 1998, 12 (24) :3797-3802

[5] DNA DAMAGE-INDUCIBLE TRANSCRIPTS IN MAMMALIAN-CELLS [J].

FORNACE, AJ ;

ALAMO, I ;

HOLLANDER, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :8800-8804

[6] GENOTOXIC-STRESS-RESPONSE GENES AND GROWTH-ARREST GENES - GADD, MYD, AND OTHER GENES INDUCED BY TREATMENTS ELICITING GROWTH ARREST [J].

FORNACE, AJ ;

JACKMAN, J ;

HOLLANDER, MC ;

HOFFMANLIEBERMANN, B ;

LIEBERMANN, DA .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES, 1992, 663 :139-153

[7] Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms [J].

Heinemeyer, T ;

Chen, X ;

Karas, H ;

Kel, AE ;

Kel, OV ;

Liebich, I ;

Meinhardt, T ;

Reuter, I ;

Schacherer, F ;

Wingender, E .

NUCLEIC ACIDS RESEARCH, 1999, 27 (01) :318-322

[8] Genomic instability in Gadd45a-deficient mice [J].

Hollander, MC ;

Sheikh, MS ;

Bulavin, DV ;

Lundgren, K ;

Augeri-Henmueller, L ;

Shehee, R ;

Molinaro, TA ;

Kim, KE ;

Tolosa, E ;

Ashwell, JD ;

Rosenberg, MP ;

Zhan, QM ;

Fernández-Salguero, PM ;

Morgan, WF ;

Deng, CX ;

Fornace, AJ .

NATURE GENETICS, 1999, 23 (02) :176-184

[9]

HOLLANDER MC, 1993, J BIOL CHEM, V268, P24385

[10]

KEARSEY JM, 1995, ONCOGENE, V11, P1675

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