Dynamic changes in connexin expression correlate with key events in the wound healing process

被引：151

作者：

Coutinho, P ^{[1
]}

Qiu, C ^{[1
]}

Frank, S ^{[1
]}

Tamber, K ^{[1
]}

Becker, D ^{[1
]}

机构：

[1] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

CELL BIOLOGY INTERNATIONAL | 2003年 / 27卷 / 07期

基金：

英国惠康基金;

关键词：

wound healing; connexin; gap junctions; epidermis; dermis; skin; communication;

D O I：

10.1016/S1065-6995(03)00077-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wound healing is a complex process requiring communication for the precise co-ordination of different cell types. The role of extracellular communication through growth factors in the wound healing process has been extensively documented, but the role of direct intercellular communication via gap junctions has scarcely been investigated. We have examined the dynamics of gap junction protein (Connexins 26, 30, 31.1 and 43) expression in the murine epidermis and dermis during wound healing, and we show that connexin expression is extremely plastic between 6 hours and 12 days post-wounding. The immediate response (6 h) to wounding is to downregulate all connexins in the epidermis, but thereafter the expression profile of each connexin changes dramatically. Here, we correlate the changing patterns of connexin expression with key events in the wound healing process. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：525 / 541

页数：17

共 33 条

[1] Connexin α1 and cell proliferation in the developing chick retina [J].