Family-based association study of DTNBP1 in 6p22.3 and schizophrenia

被引：111

作者：

Tang, JX

Zhou, J

Fan, JB

Li, XW

Shi, YY

Gu, NF

Feng, GY

Xing, YL

Shi, JG

He, L

机构：

[1] Shanghai Jiao Tong Univ, Bio X Life Sci Res Ctr, Shanghai 200030, Peoples R China

[2] Chinese Acad Sci, Shanghai Res Ctr Life Sci, Shanghai 200031, Peoples R China

[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China

[4] Xian Inst Mental Hlth, Xian, Peoples R China

来源：

MOLECULAR PSYCHIATRY | 2003年 / 8卷 / 08期

关键词：

D O I：

10.1038/sj.mp.4001287

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DTNBP1 in 6p22.3, the human ortholog of the mouse dysbindin gene, has recently been reported to be associated with schizophrenia in Irish high density pedigrees. In the present study, transmission/disequlibrium tests of haplotypes, on the basis of 7 SNPs within DTNBP1 genotyped in 233 Han Chinese trios, revealed a significant association with the disease. The results partially support the previous studies and indicate that the DTNBP1 gene may play a significant role in the etiology of schizophrenia in Han Chinese.

引用

收藏

页码：717 / 718

页数：2

相关论文

共 11 条

[1] Knocking signalling out of the dystrophin complex [J].

Bredt, DS .

NATURE CELL BIOLOGY, 1999, 1 (04) :E89-E91

[2] A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission [J].

Clayton, D .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) :1170-1177

[3] A family-based and case-control association study of the NOTCH4 gene and schizophrenia [J].

Fan, JB ;

Tang, JX ;

Gu, NF ;

Feng, GY ;

Zou, FG ;

Xing, YL ;

Shi, JG ;

Zhao, SM ;

Zhu, SM ;

Ji, LP ;

Sun, WW ;

Zheng, YL ;

Liu, WQ ;

Breen, G ;

Clair, DS ;

He, L .

MOLECULAR PSYCHIATRY, 2002, 7 (01) :100-103

[4] High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR [J].

Germer, S ;

Holland, MJ ;

Higuchi, R .

GENOME RESEARCH, 2000, 10 (02) :258-266

[5] Maturation and maintenance of the neuromuscular synapse: Genetic evidence for roles of the dystrophin-glycoprotein complex [J].

Grady, RM ;

Zhou, H ;

Cunningham, JM ;

Henry, MD ;

Campbell, KP ;

Sanes, JR .

NEURON, 2000, 25 (02) :279-293

[6]

Kendler KS, 1996, AM J MED GENET, V67, P179, DOI 10.1002/(SICI)1096-8628(19960409)67:2<179::AID-AJMG8>3.0.CO

[7]

2-N

[8] AN EXTENDED TRANSMISSION/DISEQUILIBRIUM TEST (TDT) FOR MULTI-ALLELE MARKER LOCI [J].

SHAM, PC ;

CURTIS, D .

ANNALS OF HUMAN GENETICS, 1995, 59 :323-336

[9]

SPITZER RL, 1992, ARCH GEN PSYCHIAT, V49, P624

[10] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia [J].

Straub, RE ;

Jiang, YX ;

MacLean, CJ ;

Ma, YL ;

Webb, BT ;

Myakishev, MV ;

Harris-Kerr, C ;

Wormley, B ;

Sadek, H ;

Kadambi, B ;

Cesare, AJ ;

Gibberman, A ;

Wang, X ;

O'Neill, FA ;

Walsh, D ;

Kendler, KS .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 71 (02) :337-348