Structure and mechanism of lysine-specific demethylase enzymes

被引：100

作者：

Anand, Ruchi

Marmorstein, Ronen ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

[2] Univ Penn, Wistar Inst, Program Gene Express & Regulat, Philadelphia, PA 19104 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2007年 / 282卷 / 49期

关键词：

D O I：

10.1074/jbc.R700027200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of histone-demethylating enzymes has revealed yet another reversible histone modification mark. In this review, we describe the structural and chemical insights that we have now derived underlying the activity of these enzymes. The recent co-crystal structures of LSD1 bound to a proparylamine-derivatized histone H3 peptide and JHDM structures bound to two different methylated histone H3 peptides illustrate the steric requirements and structural basis for substrate specificity.

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收藏

页码：35425 / 35429

页数：5

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[1]

[Anonymous], 2002, GENOME BIOL

[2] The PHD finger, a nuclear protein-interaction domain [J].

Bienz, M .

TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (01) :35-40

[3] Structure-function relationships in flavoenzyme-dependent amine oxidations. A comparison of polyamine oxidase and monoamine oxidase. [J].

Binda, C ;

Mattevi, A ;

Edmondson, DE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :23973-23976

[4] Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders [J].

Binda, C ;

Newton-Vinson, P ;

Hubálek, F ;

Edmondson, DE ;

Mattevi, A .

NATURE STRUCTURAL BIOLOGY, 2002, 9 (01) :22-26

[5] The many colours of chromodomains [J].

Brehm, A ;

Tufteland, KR ;

Aasland, R ;

Becker, PB .

BIOESSAYS, 2004, 26 (02) :133-140

[6] DISTRIBUTION AND TURNOVER OF LABELED METHYL GROUPS IN HISTONE FRACTIONS OF CULTURED MAMMALIAN-CELLS [J].

BYVOET, P ;

SHEPHERD, GR ;

NOLAND, BJ ;

HARDIN, JM .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1972, 148 (02) :558-&

[7] The need for guidelines in publication of peptide and protein identification data - Working group on publication guidelines for peptide and protein identification data [J].

Carr, S ;

Aebersold, R ;

Baldwin, M ;

Burlingame, A ;

Clauser, K ;

Nesvizhskii, A .

MOLECULAR & CELLULAR PROTEOMICS, 2004, 3 (06) :531-533

[8] Structural insights into histone demethylation by JMJD2 family members [J].

Chen, Zhongzhou ;

Zang, Jianye ;

Whetstine, Johnathan ;

Hong, Xia ;

Davrazou, Foteini ;

Kutateladze, Tatiana G. ;

Simpson, Michael ;

Mao, Qilong ;

Pan, Cheol-Ho ;

Dai, Shaodong ;

Hagman, James ;

Hansen, Kirk ;

Shi, Yang ;

Zhang, Gongyi .

CELL, 2006, 125 (04) :691-702

[9] Histone deimination antagonizes arginine methylation [J].

Cuthbert, GL ;

Daujat, S ;

Snowden, AW ;

Erdjument-Bromage, H ;

Hagiwara, T ;

Yamada, M ;

Schneider, R ;

Gregory, PD ;

Tempst, P ;

Bannister, AJ ;

Kouzarides, T .

CELL, 2004, 118 (05) :545-553

[10] Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes [J].

Da, GP ;

Lenkart, J ;

Zhao, KH ;

Shiekhattar, R ;

Cairns, BR ;

Marmorstein, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (07) :2057-2062

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