Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis

被引：70

作者：

Deng, Shaohua ^{[1
]}

Xi, Yebin ^{[1
]}

Wang, Hong ^{[1
]}

Hao, Jing ^{[1
]}

Niu, Xiaoyin ^{[1
]}

Li, Weiyi ^{[1
]}

Tao, Yue ^{[2
]}

Chen, Guangjie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Dept Immunol, Inst Med Sci,Shanghai Inst Immunol, Shanghai 200030, Peoples R China

[2] Guanghua Rheumatol Hosp, Shanghai, Peoples R China

来源：

CELLULAR IMMUNOLOGY | 2010年 / 265卷 / 02期

关键词：

Vasoactive intestinal peptide (VIP); CD4(+) CD25(+) regulatory T cells (Tregs); Th17; Collagen-induced arthritis (CIA); Autoimmune disease; RHEUMATOID-ARTHRITIS; T-CELLS; BONE DESTRUCTION; DEFICIENT MICE; DIFFERENTIATION; IL-17; OSTEOCLASTOGENESIS; AUTOIMMUNITY; INFLAMMATION; DISEASE;

D O I：

10.1016/j.cellimm.2010.07.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Vasoactive intestinal peptide (VIP) is a well-known anti-inflammatory neuropeptide. The capacity of VIP can be exhibited through inhibiting inflammatory responses, shifting the Th1/Th2 balance in favor of anti-inflammatory Th2 immunity and inducing regulatory T cells (Tregs) with suppressive activity. In addition to pro-inflammatory Th1 response, Th17 are also believed to play important roles in the pathogenesis of rheumatoid arthritis (RA). In this study, we used collagen-induced arthritis (CIA) model in Wistar rats to investigate the role of VIP in the balance of CD4(+) CD25(+) Tregs and Th17 on RA. Data presented here showed that administration of VIP decreased incidence and severity of CIA. Disease suppression was associated with the upregulation of CD4(+) CD25(+). Tregs, downregulation of Th17- and Th1-type response and influence on the RANK/RANKL/OPG system. The results provide novel evidence that the therapeutic effects of VIP on CIA rats were associated with the balance of CD4+ CD25+ Tregs and Th17. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：105 / 110

页数：6

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