Functions of TCR and pre-TCR subunits: Lessons from gene ablation

被引：56

作者：

Malissen, B

Malissen, M

机构：

[1] Centre d'Immunologie, INSERM-CNRS de Marseille-Luminy, Marseille, Cedex 9

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0952-7915(96)80129-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent gene-targeting experiments have highlighted the existence of checkpoints that ensure that alpha beta T cells do not complete intrathymic differentiation if they have not attained certain landmark events. These 'proofreading' mechanisms operate by way of the pre-TCR and TCR complexes, which are sequentially expressed during T-cell development. These complexes are likely to signal via their associated CD3 subunits. By activating intracellular effecters, the CD3 subunits probably modulate gene expression profiles and drive the maturing alpha beta T cells through a precise developmental sequence.

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页码：383 / 393

页数：11

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