The human Y chromosome, in the light of evolution

被引：152

作者：

Lahn, BT

Pearson, NM

Jegalian, K

机构：

[1] Univ Chicago, Howard Hughes Med Inst, Dept Human Genet, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[3] NHGRI, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 03期

关键词：

D O I：

10.1038/35056058

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Most eukaryotic chromosomes, akin to messy toolboxes, store jumbles of genes with diverse biological uses. The linkage of a gene to a particular chromosome therefore rarely hints strongly at that gene's function. One striking exception to this pattern of gene distribution is the human Y chromosome. far from being random and diverse, known human Y-chromosome genes show just a few distinct expression profiles. Their relative functional conformity reflects evolutionary factors inherent to sex-specific chromosomes.

引用

页码：207 / 216

页数：10

共 108 条

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