Electrostatic Stabilization of a Native Protein Structure in the Gas Phase

被引：112

作者：

Breuker, Kathrin ^{[1
,2
]}

Brueschweiler, Sven ^{[3
]}

Tollinger, Martin ^{[1
,3
]}

机构：

[1] Univ Innsbruck, Inst Organ Chem, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, CMBI, A-6020 Innsbruck, Austria

[3] Max F Perutz Labs, A-1030 Vienna, Austria

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 04期

基金：

奥地利科学基金会;

关键词：

electron capture dissociation; electrostatic interactions; gas phase; native mass spectrometry; protein structure; DISSOCIATION MASS-SPECTROMETRY; CAPTURE DISSOCIATION; CYTOCHROME-C; ELECTROSPRAY-IONIZATION; IONS; SPECTROSCOPY; EVOLUTION; CELL;

D O I：

10.1002/anie.201005112

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One, two, three, whee! After transfer into the gas phase, the three-helix bundle protein KIX is sufficiently stabilized by electrostatic interactions to compensate for the loss of hydrophobic bonding. It thus retains its global fold on a timescale of more than 4 s. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：873 / 877

页数：5

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