Can autophagy promote longevity?

被引：348

作者：

Madeo, Frank ^{[1
]}

Tavernarakis, Nektarios ^{[2
]}

Kroemer, Guido ^{[3
,4
,5
,6
,7
]}

机构：

[1] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria

[2] Fdn Res & Technol, Inst Mol Biol & Biotechnol, Iraklion 71110, Crete, Greece

[3] INSERM, U848, F-94805 Villejuif, France

[4] Inst Gustave Roussy, Villejuif, France

[5] Ctr Rech Cordeliers, Paris, France

[6] Hop Europeen Georges Pompidou, AP HP, Paris, France

[7] Univ Paris 05, Paris, France

来源：

NATURE CELL BIOLOGY | 2010年 / 12卷 / 09期

基金：

欧洲研究理事会; 奥地利科学基金会;

关键词：

LIFE-SPAN EXTENSION; CELL-SURVIVAL; CALORIC RESTRICTION; RESVERATROL; APOPTOSIS; GENES; SIRT1; YEAST; ACTIVATORS; DROSOPHILA;

D O I：

10.1038/ncb0910-842

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations.

引用

收藏

页码：842 / 846

页数：5

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