Messenger RNA surveillance systems monitoring proper translation termination

被引：31

作者：

Akimitsu, Nobuyoshi ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Inst Biol Resources & Funct, Tsukuba, Ibaraki 3058566, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2008年 / 143卷 / 01期

关键词：

mRNA quality control; mRNA surveillance; ribosome; stop codon; translation;

D O I：

10.1093/jb/mvm204

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Organisms have evolved an elaborate set of quality control systems to ensure the fidelity of the genetic information flow. The mRNA surveillance systems work in this context by monitoring the quality of mRNAs to ensure that they are suitable for translation. In this review, recent achievements in the investigation of mRNA surveillance pathways, including nonsense-mediated mRNA decay and nonstop-mediated mRNA surveillance pathway, will be discussed.

引用

页码：1 / 8

页数：8

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