New triterpenoid saponins from the sponge Erylus nobilis

被引：27

作者：

Shin, J

Lee, HS

Woo, L

Rho, JR

Seo, Y

Cho, KW

Sim, CJ

机构：

[1] Korea Ocean Res & Dev Inst, Marine Nat Prod Lab, Seoul 425600, South Korea

[2] Hannam Univ, Dept Biol, Taejeon 300791, South Korea

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 06期

关键词：

D O I：

10.1021/np010047d

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Erylosides G-J (1-4), four new triterpenoid saponins, were isolated from the sponge Erylus nobilis collected from Jaeju Island, Korea. On the basis of the results of combined chemical and spectral analyses, the structures of the aglycones were determined to be lanostane-based, modified penasterols. The oligosaccharide portions were composed of one unit each of L-arabinose, D-galactose, and 2-N-acetyl-D-glucosamine (1 and 3) or two units of L-arabinose and one unit of 2-N-acetyl-D-glucosamine (2 and 4). These compounds exhibited moderate cytotoxicty against a human leukemia cell line.

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页码：767 / 771

页数：5

相关论文

共 20 条

[1] Ulososide B, a new unusual norlanostane-triterpene glycoside and its genuine aglycone from the Madagascar sponge Ulosa sp. [J].

Antonov, AS ;

Kalinovsky, AI ;

Stonik, VA .

TETRAHEDRON LETTERS, 1998, 39 (22) :3807-3808

[2] ASSIGNMENT OF ANOMERIC CONFIGURATION AND IDENTIFICATION OF CARBOHYDRATE RESIDUES BY C-13 NMR .1. GALACTOPYRANOSIDES AND GLUCOPYRANOSIDES AND FURANOSIDES [J].

BEIER, RC ;

MUNDY, BP ;

STROBEL, GA .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1980, 58 (24) :2800-2804

[3]

Cafieri F, 1999, EUR J ORG CHEM, V1999, P231

[4] THE STRUCTURE OF ERYLOSIDE A, A NEW ANTITUMOR AND ANTIFUNGAL 4-METHYLATED STEROIDAL GLYCOSIDE FROM THE SPONGE ERYLUS-LENDENFELDI [J].

CARMELY, S ;

ROLL, M ;

LOYA, Y ;

KASHMAN, Y .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (01) :167-170

[5] PENASTEROL, A NOVEL ANTILEUKEMIC STEROL FROM THE OKINAWAN MARINE SPONGE PENARES SP [J].

CHENG, JF ;

KOBAYASHI, J ;

NAKAMURA, H ;

OHIZUMI, Y ;

HIRATA, Y ;

SASAKI, T .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (08) :2403-2406

[6] STRUCTURE CHARACTERIZATION BY 2-DIMENSIONAL NMR-SPECTROSCOPY, OF 2 MARINE TRITERPENE OLIGOGLYCOSIDES FROM A PACIFIC SPONGE OF THE GENUS ERYLUS [J].

DAURIA, MV ;

PALOMA, LG ;

MINALE, L ;

RICCIO, R .

TETRAHEDRON, 1992, 48 (03) :491-498

[7] POLYOXYGENATED STEROIDS OF MARINE ORIGIN [J].

DAURIA, MV ;

MINALE, L ;

RICCIO, R .

CHEMICAL REVIEWS, 1993, 93 (05) :1839-1895

[8] SARASINOSIDES D-G - 4 NEW TRITERPENOID SAPONINS FROM THE SPONGE ASTEROPUS-SARASINOSUM [J].

ESPADA, A ;

JIMENEZ, C ;

RODRIGUEZ, J ;

CREWS, P ;

RIGUERA, R .

TETRAHEDRON, 1992, 48 (40) :8685-8696

[9]

FAULKNER DJ, 2000, NAT PROD REP, V17, P5

[10] ERYLOSIDE-E FROM AN ATLANTIC SPONGE ERYLUS-GOFFRILLERI [J].

GULAVITA, NK ;

WRIGHT, AE ;

KELLYBORGES, M ;

LONGLEY, RE ;

YARWOOD, D ;

SILLS, MA .

TETRAHEDRON LETTERS, 1994, 35 (25) :4299-4302